SOCIAL ANXIETY AND SOCIAL COMPETENCE AS DETERMINANTS OF BULLYING BEHAVIOR: A CASE STUDY OF HYDERABAD, SINDH, PAKISTAN

This study investigated the social anxiety and social competence as determinants of bullying student’s behavior of among college students in Pakistan. To define the level of social anxiety and bullying behavior of students which self, peers, regard fatalities as having poorer social skills through 20 behavior’s/competences. A convenience sample of 230 pupils aged between 12 to 14 years (130 girls and 100 boys) provided self-report and peer-report data. They were taken from four colleges of Hyderabad city Sindh Pakistan, like as I mentioned zubaida government degree Girls College Hyderabad, Hayat Girls College Hyderabad, Government Boys degree College Qasimabad, Government degree College kohsar Hyderabad. Furthermore the researcher has used quantitative method survey questionnaire distribute to the respondents for data collection. Analysis through SPSS version 26 Post hoc multiple comparisons of social anxiety and social competence of bullying behavior of students experiences with social anxiety in college students. Study situations using Mann–Whitney U tests demographic information of respondent’s, analysis reliability analysis. In results researcher has found some of the main cause behind this study social anxiety and bullying behavior of students playing negative role in the society. This research will be fruitful for the scholars and policy makers. Article visualizations

Manuscript writing and publication workshop: An invoking pilot study on enhancing cognitive research capabilities in health sciences institutes of Pakistan

Background: With an upsurge in research in developing countries, researchers from allied sciences need to augment their skills for disseminating research work worldwide. Training workshop is one of the quick interventions which can enhance writing skills and ease research publication.Objective: We designed this research to explore the perception of the faculty of different higher education institutes (HEIs) regarding manuscript writing and to assess the impact of these workshops in the improvement of cognitive capabilities of preliminary researchers in Pakistan.Methodology: We conducted workshops in HEIs of Sindh, Pakistan. Contents of the workshop covered algorithm of writing manuscript and related descriptions, choice of quality journals, correspondence with the editor, and dealing with rejection. The knowledge of the participants was assessed by 15 items pre and post evaluation tests. McNamar\u27s test assessed the significance of the change in knowledge. Kruskal Wallis test was performed to check the difference in the opinion of workshop quality among different institutes.Results: A significant improvement was observed in participants’ knowledge on the readers’ prospects (P=0.001), the algorithm of writing (P\u3c0.001), interpretations of results (P\u3c0.001), and selection quality journal for publication (P \u3c0.001). The agreement with the workshop\u27s quality based on need, knowledge, and content was above average.Conclusion: The participants’ response regarding the effectiveness of manuscript writing for publication workshop was overwhelmingly positive, and there was a significant impact on the knowledge of the participants. There is a need for research training that will help for better capacity building in different HEIs of Pakistan

ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations.

The environmental impact of metal complexes such as organotin(IV) compounds is of increasing concern. Genotoxic effects of organotin(IV) compounds (0.01 μg/ml, 0.1 μg/ml or 1.0 μg/ml) were measured using the alkaline single-cell gel electrophoresis (comet) assay to measure DNA single-strand breaks (SSBs) and the cytokinesis-block micronucleus (CBMN) assay to determine micronucleus formation. Biochemical-cell signatures were also ascertained using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy. In the comet assay, organotin(IV) carboxylates induced significantly-elevated levels of DNA SSBs. Elevated micronucleus-forming activities were also observed. Following interrogation using ATR-FTIR spectroscopy, infrared spectra in the biomolecular range (900 cm-1 – 1800 cm-1) derived from organotin-treated MCF-7 cells exhibited clear alterations in their biochemical-cell fingerprint compared to control-cell populations following exposures as low as 0.0001 μg/ml. Mono-, di- or tri-organotin(IV) carboxylates (0.1 μg/ml, 1.0 μg/ml or 10.0 μg/ml) were markedly cytotoxic as determined by the clonogenic assay following treatment of MCF-7 cells with ≥ 1.0 μg/ml. Our results demonstrate that ATR-FTIR spectroscopy can be applied to detect molecular alterations induced by organotin(IV) compounds at sub-cytotoxic and sub-genotoxic concentrations. This biophysical approach points to a novel means of assessing risk associated with environmental contaminants

A comparison between wellness awareness among medical students

Objective: To assess and compare the dimensions of spiritual wellness as elements of quality care in medical students of private and public medical universities.Methods: The cross-sectional study was carried out at private and public medical universities in Karachi from November 2013 to January 2015.Students from both genders and all ethnic groups19-23 years of age were included. The responses of spiritual wellness were obtained and evaluated on a four-point Likert\u27s scale; score ranging from 0-3. Data was analysed using Predictive Analysis Software version 18.Results: Out of 736 students, 286 (38.9%) were from public medical universities and 450 (61.1%) were from private-sector institutions. Students of both types of universities were aware of the concept of spiritual wellness but the level of awareness needed scaling up. Public-sector students had a stronger will, were more physically and mentally alert, more compassionate, empathetic and enthusiastic about their relationship with patients than their private-sector counterparts (p\u3c0.05). They used spiritual wellness as a coping strategy to deal with difficult situations through religious activities. Though attentive listening was a predominant feature in both groups, the use of communication skills required particular attention to improve the element of compassionate care

IMPACT OF TEACHERS’ BEHAVIOR ON THE MOTIVATION OF STUDENTS AT HIGH SCHOOL LEVEL: EMPIRICAL STUDY OF DISTRICT HYDERABAD, SINDH, PAKISTAN

Education is considered as an authentic tool for rapid nation building, empowerment, prosperity and economic development. The quality of education remained main issue for Policy makers and curriculum designer. Policy makers have dedicated huge amount of time and energy to provide quality education. Mainly focus of quality betterment relies was associated with infrastructural development like, buildings, furniture, laboratories, libraries and play grounds. In this relation, curriculum designing, hiring of new trained teacher, external environment, nutrition, poverty alleviation also remained priority for betterment of education. But the major element of education is related with student psychology. One major factor is being over shadowed; the motivation of the students, even with the best administrators, highly qualified faculty, curriculum and materials in place, if students are not motivated, to learn and excel, the achievement of goal will become difficult. Therefore, current study major purpose was to investigate the impact of teacher’s behavior on the motivation of students at high school. The study based on inductive approach. The quantitative technique was employed for data collection. The data were analyzed through statistical package for social science 24 version for windows. The findings of study revealed that impact of teacher’s behavior on the motivation of students is positively associated. The teacher motivation has great impact on student attitude, learning, understanding and mental development. Therefore, policy makers, curriculum designers should focus on motivation of students. Article visualizations

Clinical evaluation of patients suffering from osteoarthritis along with prevalence, pharmacological and non-pharmacological treatment

Background: Osteoarthritis is a disorder of joints that most often influences the knee, spine, hip, and small hands joints. It is one of the common types of arthritis. It can lead to reduced mobility in elder patients. Primary objective: The aim of the project is to evaluate the current etiology, pathogenesis, investigations, and management of osteoarthritis. Methods/Design: The history of patients suffering from osteoarthritis was collected on a designed questionnaire which includes age, gender, job status, duration of disease, weight, pain, and current medical history. Setting: Data was taken from different people in the community Participants: Data from 50 patients were taken. Intervention: This work will discuss the challenges of developing good quality outcome measures for use in large-scale multicenter clinical trials for new osteoarthritis treatments, especially disease-modifying osteoarthritis drugs. Primary Outcome Measures: The data evaluation showed that this disease is most common in women than men having a weight greater than 50kg. Results: Most persons suffering from this disease were unemployed and had limited physical activities, and the maximum had complaints of knee pain and shoulder pain. A few patients complained of neck, elbow, feet, and backbone pain. Most were suffering from other concomitant diseases along with osteoarthritis, and a few were diagnosed with osteoarthritis only. Conclusion: This study clearly showed the prime factors involved in osteoarthritis which may help the community to avoid those factors to increase the quality of life

One-pot synthesis of crystalline structure: Nickel-iron phosphide and selenide for hydrogen production in alkaline water splitting

Electrocatalytically active nanocomposites play a vital role in energy generation, conversion, and storage technologies. Transition metal-based catalysts such as nickel and iron and their pnictide (phosphide), and chalcogenide (selenide) compounds exhibit good activity for hydrogen evolution reaction (HER) in the alkaline environment. In this study, transition metals-based catalysts (Ni-P-Se, Fe-P-Se, and Ni-Fe-P-Se) solutions were prepared using a simple one-pot method. Prepared solutions were deposited on Ni foam, and different characterization techniques were used to determine the composition, structure, and morphology of as-prepared catalysts. Furthermore, it was found that Ni-Fe-P-Se as a cathode material showed better HER performance compared to other investigated materials with the overpotential value of 316 mV at 10 mA cm-2 current density and 89 mV dec-1 Tafel slope value. The stability tests of the as-prepared catalyst confirmed that the synergistic effect between various elements enhances the electrocatalytic performance for up to 24 hours, providing a fair, stable nature of Ni-Fe-P-Se based sample

Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fracture

Objective: To assess the safety and efficacy of percutaneous vertebroplasty in the treatment of single level Osteo-porotic Vertebral Compression Fractures (OVCF). Study Design: This was a case series study. Place and Duration of Study: Department of Neurosurgery Unit I, Lahore General Hospital, Lahore from Jan-uary 2012 to January 2014.Methodology: All 57 patients received PVP in the current study. Feasibility of a unilateral approach was judged before surgery using the 64 – slice helical computed tomography (CT) multiplanar reconstruction technique, a 3D accurate puncture plan was then determined. The skin bone distance, puncture angle and needle insertion depth were recorded during surgery. 2D CT rechecking was performed for any complication at day 1 after operation. Preoperative and postoperative numerical data were compared patients fulfilling the inclusion criteria were given time in the out – patient department for vertebroplasty. Patients who had a neoplastic etiology (meta-stasis or myeloma), infection, neural compression, traumatic fracture, neurological deficit, spinal stenosis, severe degenerative diseases of the spine or previous surgery at the involved vertebral body were excluded from our study. Prior to vertebroplasty the patient’s level of pain was recorded by using the visual analogue scale method: a scale of 0 – 10, with 10 indicating the most pain. After vertebroplasty, patients were asked whether their pain was completely relieved, partially relieved, unchanged, or worse. The post vertebroplasty visual analogue scale score were recorded on the day of vertebroplasty immediately after the end of the procedure and at 24 hours and then at the follow up visits at 2 weeks, 1 month, 3 months, 6 months, and 1 year intervals. Results: In this study there were 20 (35.1%) male and 37 (64.9%) female patients. The mean age of patients was 59.12 ± 12.40 years with minimum and maximum age 39-88 years respectively. On pre procedure assessment, fractures of L1, L2 and L3 were seen in 10 (17.5%), 6 (10.5%) and 5 (8.8%) respectively while T11 and T12 were seen in 6 (10.5%) and 16 (28.15%) respectively. Mean pre and postoperative pain on VAS was 7.91 ± 1.17 and 1.17 ± 1.45. After surgery mean difference in pain score was 6.73 ± 1.90 with fulfillment of normality assumptions (Kolmogorov-Smirnov Z = 1.18, p-value = 0.123). On applying paired sample t-test significant improvement in pain was found after surgery, t=26.71, p-value < 0.001. Mean cement volume and vertebral collapse was 6.42 ± 1.60 and 29.29 ± 4.19 respectively.Conclusion: Vertebroplasty is safe and effective procedure for osteoporotic vertebral collapse and its a day care procedure and can be performed safely under local anaesthesia

First Comprehensive In Silico

GalNAc-T1, a key candidate of GalNac-transferases genes family that is involved in mucin-type O-linked glycosylation pathway, is expressed in most biological tissues and cell types. Despite the reported association of GalNAc-T1 gene mutations with human disease susceptibility, the comprehensive computational analysis of coding, noncoding and regulatory SNPs, and their functional impacts on protein level, still remains unknown. Therefore, sequence- and structure-based computational tools were employed to screen the entire listed coding SNPs of GalNAc-T1 gene in order to identify and characterize them. Our concordant in silico analysis by SIFT, PolyPhen-2, PANTHER-cSNP, and SNPeffect tools, identified the potential nsSNPs (S143P, G258V, and Y414D variants) from 18 nsSNPs of GalNAc-T1. Additionally, 2 regulatory SNPs (rs72964406 and #x26; rs34304568) were also identified in GalNAc-T1 by using FastSNP tool. Using multiple computational approaches, we have systematically classified the functional mutations in regulatory and coding regions that can modify expression and function of GalNAc-T1 enzyme. These genetic variants can further assist in better understanding the wide range of disease susceptibility associated with the mucin-based cell signalling and pathogenic binding, and may help to develop novel therapeutic elements for associated diseases